Klf4 function

Author: orjz

August undefined, 2024

WebApr 8, 2024 · Evidently, KLF4 plays an important role in the vast majority of tumors, including lung, breast, prostate, colorectal, pancreatic, liver, ovarian, esophageal, bladder, and brain … WebAug 28, 2013 · General functions of KLF4 3.1. Inhibition of cell proliferation KLF4 is known to induce growth arrest, inhibiting cell proliferation by regulating the expression of key cell …

UniProt

WebKLF4 belongs to the Kruppel-like factor (KLF) family, a group of conserved zinc finger TFs that regulates essential biological processes such as proliferation and development. Reflecting pioneer factor activity, KLF4 uses two out of its three zinc fingers to target a GC-rich hexameric motif enriched within nucleosomal targets22 ( Fig. 7.2 C). WebMar 19, 2010 · Transcription factor Kruppel-like factor 4 (Klf4) is essential for somatic cell reprogramming. In addition, Klf4 seems to play a redundant role along with other Klf family proteins in embryonic stem (ES) cell self-renewal. However, how Klf4 regulates ES cell self-renewal and somatic cell reprogramming is still poorly understood. Here we report that … dongixaojie

Roles of KLF4 and AMPK in the inhibition of glycolysis by ... - PNAS

WebMay 28, 2024 · En el año 2006 fueron generadas las células madre plu- ripotenciales inducidas (IPs). Las IPs son células adultas diferenciadas, pero tras la inducción con la inserción de 4 genes en su núcleo (Oct4, Sox2, c-Myc, y Klf4), se comportan como células embrionarias con plasticidad histogenética. WebMar 2, 2024 · KLF4 is a transcription factor that plays significant tumor-suppressive roles in the pathogenesis and progression of HCC, such as promoting tumor differentiation, suppressing epithelial-mesenchymal transition, and restraining tumor growth and metastasis ( Sun et al., 2024 ). WebKLF4 T Cell In Vitro Human Umbilical Vein Endothelial Cell Endothelial Nitric Oxide Synthase Mitogen Activated Protein Kinase 7 View all Topics Add to Mendeley Set alert About this page Genetics of Cardiovascular Disease Peter Novodvorsky, Timothy J.A. Chico, inProgress in Molecular Biology and Translational Science, 2014 6Summary don giovanni\u0027s bakery

Klf4 Kruppel-like factor 4 (gut) [ (house mouse)] - National Center …

KLF4 - an overview ScienceDirect Topics

WebApr 11, 2024 · During aging, the protective function of mucus barrier is significantly reduced among which changes in colonic mucus barrier function received the most attention. Additionally, the incidence of colon-related diseases increases significantly in adulthood, posing a threat to the health of the elderly. However, the specific changes in colonic … WebNov 25, 2010 · KLF4 (gut Krüppel-like factor) was initially identified in the epithelial lining of the gut and skin. 39 Indeed, KLF4 knockout mice exhibit abnormal epidermal differentiation and, as a consequence, die within hours after birth 40 ; in addition, KLF4 has been found to be essential for colonic goblet cell differentiation. 41 KLF4 has also been … don giovanni don juanWebDec 10, 2024 · KLF4 expression is upregulated in PDGFR-β + cells and their lineage during disease pathogenesis. Reduction of KLF4 in PDGFR-β + cells attenuates fibrosis, at least in part by downregulating... dongjae kidnap

"WebJun 28, 2013 · The Krüppel-like factor 4 is a DNA-binding transcriptional regulator that regulates a diverse array of cellular processes, including development, differentiation, … " - Klf4 function

Klf4 function

WebNov 12, 2015 · The function of KLF4 in the kidney is still not well understood. In this review, we highlight recent findings on how KLF4 regulates renal fibrosis, with the aim of evaluating the potential of KLF4 as a novel therapeutic target for renal fibrosis. The biological characteristics of KLF4. WebFeb 19, 2024 · KLF4 is a therapeutically tractable brake on fibroblast activation that promotes resolution of pulmonary fibrosis. Penke LR, et al. JCI Insight, 2024 Aug 22. PMID 35852857, Free PMC Article. Decreased Krüppel-like factor 4 in adenomyosis impairs decidualization by repressing autophagy in human endometrial stromal cells.

Did you know?

WebKlf4 inhibits proliferation through activation of p21Cip1/Waf1, and direct suppression of cyclin D1 and cyclin B1 gene expression. Both Klf4 & Klf5 proteins act on the Klf4 … WebThere is evidence to suggest that transcription factor KLF4 plays a crucial role in the progression of breast carcinoma, 14 squamous cell carcinoma, 15 lung cancer, 16 and …

WebUsing next-generation sequencing data, we identified the binding of PS-induced Krüppel-like factor 4 (KLF4), which functions as a pioneer transcription factor, binding to the GCKR promoter to change the chromatin structure for transactivation of GCKR. At the posttranslational level, PS-activated AMP-activated protein kinase (AMPK ... WebNov 25, 2024 · Here, we report that Krüppel-like factor 4 (KLF4) is a critical regulator of the exhaustion process, promoting the cytolytic effector function of exhausted CD8 T cells. …

WebApr 1, 2024 · TL;DR: Results demonstrate that autophagy is an important mechanism related to Klfs in smooth muscle cells during AAA formation, and Chromatin immunoprecipitation assays demonstrated that Klf4, Klf2, and Zfp148 separately bind autophagic genes in smooth Muscle cells following elastase treatment. Abstract: Abdominal aortic aneurysms … WebKLF4 is demonstrated with the function of re-activating the CD8 T cell by stimulating c-Jun generation in the immune response against cancer [37]. In addition to the functions mentioned earlier, KLF4 has been found to strongly increase the expression of the MMP gene in chondrocytes, which is beneficial for cartilage development [38] .

WebConclusions: KLF4 may function as a tumor suppressor gene in urothelial cancer since down-regulation of KLF4 by promoter hypermethylation would promote cancer progression. In addition, decreased expression of KLF4 or its promoter hypermethylation may have predictive value for early recurrence in patients with nonmuscle invasive bladder cancer.

WebBackground & aims: Krüppel-like factor 4 (KLF4) is a transcription factor associated with tumor suppression and oncogenesis. KLF4 suppresses pancreatic tumorigenesis by unknown mechanisms; we investigated alterations that might affect KLF4 function and lead to tumor formation. dongi\\u0027s pizzaWebMay 5, 2024 · The Krüppel-like factor 4 (KLF4; also called gut-enriched Krüppel-like factor or GKLF) was first isolated by Shields et al., from a NIH3T3 cDNA library (Shields et al., … r0 ratio\u0027sWebJan 3, 2024 · Importantly, KLF4 overexpression boosted activation of the IL-6 promoter, whereas KLF4 knockdown suppressed activation of the IL-6 promoter , implicating that KLF4 functions as a positive regulator of IL-6 gene transcription in GMCs exposed to sublytic C5b-9. KLF4 Activates IL-6 Promoter by Binding to Proximal Binding Site dongi\u0027sWebMar 21, 2024 · KLF4 (KLF Transcription Factor 4) is a Protein Coding gene. Diseases associated with KLF4 include Epilepsy, Idiopathic Generalized 15 and Familial Adenomatous Polyposis . Among its related pathways are … r0 rattlesnake\\u0027sWebDec 3, 2024 · Both KLF4 and Sp5 have been shown to regulate naive pluripotency in part through the transcriptional regulation of Nanog, whose downregulation marks the exit of ESCs from the naive state into a state that is primed for lineage specification 29 – 31. Interestingly, we observed downregulation of both Nanog and Klf4 in I-BRD9-treated ESCs … don giovanni\u0027s knutsfordWebApr 12, 2024 · KLF4 is required for normal smooth muscle cell function and coverage of resistance arteries. Transgenic mice with overexpression of KLF4 were subjected to … don giovanni\u0027s bristolWebSep 30, 2015 · KLF4 is an important regulator of cell-fate decision, including DNA damage response and apoptosis. We identify a novel interplay between protein modifications in regulating KLF4 function. r0 rabbit\u0027s